Patient Safety Alert: Pyridoxine (Vitamin B6) and Restless Legs Symptoms

You may have come across or been recommended Pyridoxine (Vitamin B6) as a supplement to help with symptoms of restless legs. While some people have found it helpful, we want to bring to your attention new safety concerns related to its use.

What’s the concern?
Recent reports have highlighted cases of nerve toxicity linked to high or prolonged use of Pyridoxine, even at doses that were previously thought to be safe. This can lead to symptoms such as numbness, tingling, or burning sensations in the hands and feet, and may be difficult to reverse once it occurs.

Why are we sharing this?
Pyridoxine is not a prescription medication, which means we often don’t know when or how it’s being used. If you’re taking it regularly for restless legs or any other reason, we recommend you stop and speak to your doctor about safer options.

What should I do now?

• Stop taking Pyridoxine unless specifically advised by your doctor.
• Talk to your healthcare provider if you have been using it and notice unusual sensations in your limbs.
• Ask us about other proven treatments for restless legs that may be more appropriate and safe for your situation.

We share this advice out of caution and care – your safety is always our top priority. If you have any questions or concerns, please don’t hesitate to contact your care team.